Salinomycin (1) exhibits a large spectrum of biological activities including the capacity to selectively eradicate cancer stem cells (CSC), making it and its derivatives promising candidates for the development of drug leads against CSC.

Showing result 1 - 5 of 53 swedish dissertations containing the word EMT. 1. Not all those who wander are lost : A study of cancer cells by digital holographic

3. Effects of salinomycin on human cancer cells a recent study revealed that salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells of different origins (34). First, it was demonstrated that salino-mycin at doses lower than those used by Gupta et al induced 2019-07-01 · Salinomycin inhibits Akt/NF-κB and induces apoptosis in cisplatin resistant ovarian cancer cells Cancer Epidemiol , 37 ( 4 ) ( 2013 ) , pp. 512 - 517 , 10.1016/j.canep.2013.02.008 Article Download PDF View Record in Scopus Google Scholar Salinomycin induces apoptosis of human colorectal cancer cells, accompanied by accumulation of dysfunctional mitochondria and reactive oxygen species. These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment.

Salinomycin cancer

Det är sedan tidigare känt att denna molekyl The thesis title is 'On the Breast Cancer Stem Cell Selectivity of Salinomycin and its Structural Analogues'. During the PhD study, I mainly focused on the effect of Influence of salinomycin treatment on division and movement of individual cancer cells cultured in normoxia or hypoxia evaluated with time-lapse digital Such cells are connected to drug resistance, metastasis, and cancer recurrence. In 2009, the polyether ionophore salinomycin was shown to exhibit selective eller ett enskilt företag inte räcker för att bekämpa cancer. Via Nätverket mot cancer driver Blodcancer- Salinomycin verkar mot cancerstamcellerna genom. Mattias K Andersson | Sahlgrenska Cancer Center the polyether ionophores monensin, salinomycin, and nigericin as novel inhibitors of MYB activity.

These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment.

Studies performed in 2011 showed that salinomycin could induce apoptosis of human cancer cells at higher concentrations. C20 amino derivatives such as ironomycin have shown to be more potent in vitro models of persister cancer cells and in vivo doi: 10.1038/nchem.2778. Promising results from a few clinical pilot studies reveal that salinomycin is able to effectively eliminate cancer stem cells and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers.

Abstract. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

Hypoxia and low pH are some of the major attributes of tumor milieu, enhancing anoikis evasion and therapy resistance. Several studies have shown that the therapeutic potential of small molecules (such as salinomycin) induced ROS production in cancer cells to inhibit anoikis resistance, invasiveness, migration, and metastasis (62, 90, 196–198

16(1). https: Glioblastoma is an aggressive cancer of the brain. It is a very fast-growing cancer that spreads quickly. Glioblastoma is the most common type of malignant brain tumor in adults.

A) Boyden chamber migration assays of different cancer cell lines during treatment. MDA-MB-436, LLC and 4T1-luc cells were treated for 18 h with 10 μM, 0.5 μM and 0.5 μM doxorubicin or 0.05 μM, 0.5 μM and 0.05 μM salinomycin, respectively. 2019-01-24 · Background Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors.
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The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics.
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Nuvarande terapeutiska paradigmer för behandling av cancer are natural products (salinomycin, abamectin and nigericin) or derivatives thereof (etoposide)

Salinomycin selectively targets cancer stem cells. The potential of salinomycin to eliminate both cancer stem cells and therapy-resistant cancer cells may characterize the compound as a novel and an efficient chemotherapeutic drug. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (SAL) has been reported to exhibit anticancer response on various types of cancer.

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Salinomycin selectively targets cancer stem cells. The potential of salinomycin to eliminate both cancer stem cells and therapy-resistant cancer cells may characterize the compound as a novel and an efficient chemotherapeutic drug.

Along with other natural ionophores, it is used commercially as a coccidiostat for poultry and a growth promoter for ruminants. 2019-05-27 · Salinomycin is a powerful cancer treatment. It is an antibiotic that’s been used to treat infections in poultry, but despite its demonstrated ability to cure human diseases like cancer and malaria, it is rarely used in humans because it would negate the need for conventional treatments like chemotherapy, radiation, and surgery. Masaya Kai, Noriko Kanaya, Shang V. Wu, Carlos Mendez, Duc Nguyen, Thehang Luu, Shiuan Chen, Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin, Breast Cancer Research and Treatment, 10.1007/s10549-015-3376-5, 151, 2, (281-294), (2015). Salinomycin kills cancer stem cells in different types of human cancers by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, mitochondrial function and other cancer stem cell (CSC) pathways.

Hypoxia and low pH are some of the major attributes of tumor milieu, enhancing anoikis evasion and therapy resistance. Several studies have shown that the therapeutic potential of small molecules (such as salinomycin) induced ROS production in cancer cells to inhibit anoikis resistance, invasiveness, migration, and metastasis (62, 90, 196–198

Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/ β -catenin signaling pathway, and other CSC pathways. 2019-05-27 · Salinomycin is a powerful cancer treatment. It is an antibiotic that’s been used to treat infections in poultry, but despite its demonstrated ability to cure human diseases like cancer and malaria, it is rarely used in humans because it would negate the need for conventional treatments like chemotherapy, radiation, and surgery. Salinomycin activates an unconventional pathway of apoptosis in human cancer cells that may contribute to the breakdown of apoptosis resistance. The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent. Salinomycin kills cancer stem cells in different types of human cancers by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, mitochondrial function and other cancer stem cell (CSC) pathways.

Salinomycin's toxicity towards cancer stem cells was further supported by recent studies in Salinomycin has recently been shown to target CSCs in different types of human cancers, including gastric cancer , lung adenocarcinoma , osteosarcoma , colorectal cancer , squamous cell carcinoma (SCC) , and prostate CSCs , suggesting that salinomycin may be effective in CSCs of many, if not all, types of human cancers, although it is currently not known whether all cancers contain subpopulations of CSCs. types of cancer, and sensitizes MDR human cancer cells.8 Exciting effects of salinomycin on cancer Gupta et al. showed that salinomycin inhibits growth of human breast cancer and decreased metastasis in non-obese diabetic (NOD)/severe combined immunodeficient (SCID) mice.7 Salinomycin caused apoptosis in human 2017-03-28 · Gupta et al. showed that salinomycin inhibits growth of human breast cancer and decreased metastasis in non-obese diabetic (NOD)/severe combined immunodeficient (SCID) mice. 7 Salinomycin caused apoptosis in human CD4 + T-cell of acute T-cell leukemia, MDR human MES-SA/Dx5 uterine sarcoma cells which express P-gp. 2 Salinomycin (1) exhibits a large spectrum of biological activities including the capacity to selectively eradicate cancer stem cells (CSC), making it and its derivatives promising candidates for the development of drug leads against CSC. Will salinomycin be a new cancer drug?